Endocrine Abstracts

Biological sex is one of nature’s most robust variables. We are leveraging sex differences to discover how hormone-responsive nodes in the brain and peripheral tissues maintain metabolic, skeletal, and cognitive health using the mouse as our model system. Findings from our research program are highly relevant to women’s health during estrogen-depleted states that include natural or drug-induced menopause commonly associated with anti-hormone breast cancer therapies. ...

Delayed puberty may occur in some boys affected with X-linked Spondyloepiphyseal dysplasia tarda (SEDT), which is caused by mutations of the gene encoding a 140 amino acid protein designated Sedlin. Sedlin interacts with the pituitary homeobox 1 (Pitx1) and steroidogenic factor 1 (SF1) transcription factors, which are involved in the development and regulation of the hypothalamic-pituitary-gonadal axis. We have therefore investigated the hypothesis that SEDT associated mutatio...